Why do old flies die?

International audienc

Simultaneous intracranial EEG and fMRI of interictal epileptic discharges in humans

Simultaneous scalp EEG–fMRI measurements allow the study of epileptic networks and more generally, of the coupling between neuronal activity and haemodynamic changes in the brain. Intracranial EEG (icEEG) has greater sensitivity and spatial specificity than scalp EEG but limited spatial sampling. We performed simultaneous icEEG and functional MRI recordings in epileptic patients to study the haemodynamic correlates of intracranial interictal epileptic discharges (IED). Two patients undergoing icEEG with subdural and depth electrodes as part of the presurgical assessment of their pharmaco-resistant epilepsy participated in the study. They were scanned on a 1.5 T MR scanner following a strict safety protocol. Simultaneous recordings of fMRI and icEEG were obtained at rest. IED were subsequently visually identified on icEEG and their fMRI correlates were mapped using a general linear model (GLM). On scalp EEG–fMRI recordings performed prior to the implantation, no IED were detected. icEEG–fMRI was well tolerated and no adverse health effect was observed. intra-MR icEEG was comparable to that obtained outside the scanner. In both cases, significant haemodynamic changes were revealed in relation to IED, both close to the most active electrode contacts and at distant sites. In one case, results showed an epileptic network including regions that could not be sampled by icEEG, in agreement with findings from magneto-encephalography, offering some explanation for the persistence of seizures after surgery. Hence, icEEG–fMRI allows the study of whole-brain human epileptic networks with unprecedented sensitivity and specificity. This could help improve our understanding of epileptic networks with possible implications for epilepsy surgery

Independent component analysis of interictal fMRI in focal epilepsy: comparison with general linear model-based EEG-correlated fMRI

The general linear model (GLM) has been used to analyze simultaneous EEG–fMRI to reveal BOLD changes linked to interictal epileptic discharges (IED) identified on scalp EEG. This approach is ineffective when IED are not evident in the EEG. Data-driven fMRI analysis techniques that do not require an EEG derived model may offer a solution in these circumstances. We compared the findings of independent components analysis (ICA) and EEG-based GLM analyses of fMRI data from eight patients with focal epilepsy. Spatial ICA was used to extract independent components (IC) which were automatically classified as either BOLD-related, motion artefacts, EPI-susceptibility artefacts, large blood vessels, noise at high spatial or temporal frequency. The classifier reduced the number of candidate IC by 78%, with an average of 16 BOLD-related IC. Concordance between the ICA and GLM-derived results was assessed based on spatio-temporal criteria. In each patient, one of the IC satisfied the criteria to correspond to IED-based GLM result. The remaining IC were consistent with BOLD patterns of spontaneous brain activity and may include epileptic activity that was not evident on the scalp EEG. In conclusion, ICA of fMRI is capable of revealing areas of epileptic activity in patients with focal epilepsy and may be useful for the analysis of EEG–fMRI data in which abnormalities are not apparent on scalp EEG

Introduction to the issue on novel and specialty fibers

The fiber optical communication revolution has been fueled by well publicized and relentless improvements of transmission fiber. Since the demonstration of the first low-loss optical fiber in 1972, there has been a continual stream of technology improvements designed to reduce impairments due to propagation loss and pulse dispersion. This steam of fiber technology has led the industry from multimode fiber operated at 800 nm, to standard single-mode fiber used at 1310 nm, then on to transmission fibers that now have attributes tuned for particular applications such as terrestrial or submarine transmission. There is every reason to believe that advances in technology will continue at the accelerating pace we have seen in the past decade, adding to the family of available transmission fibers. The special issue is dedicated to the increasing family of specialty fibers, and includes exciting papers on fibers for gratings and a unique amplification fiber. Fibers for specialized transmission spanning a broad range of applications are also described in three important articles. As is appreciated by all optical scientists, progress can be made only as quickly as one can improve measurement capabilities, so the issue includes two excellent papers dealing with the important measurement of chromatic dispersion.We hope that you enjoy the papers of this issue as much as we the editors have enjoyed reading and reviewing them

Rapid Real-Time Interdisciplinary Ocean Forecasting Using Adaptive Sampling and Adaptive Modeling and Legacy Codes: Component Encapsulation Using XML

Abstract. We present the high level architecture of a real-time inter-disciplinary ocean forecasting system that employs adaptive elements in both modeling and sampling. We also discuss an important issue that arises in creating an integrated, web-accessible framework for such a system out of existing stand-alone components: transparent support for handling legacy binaries. Such binaries, that are most common in scien-tific applications, expect a standard input stream, maybe some command line options, a set of input files and generate a set of output files as well as standard output and error streams. Legacy applications of this form are encapsulated using XML. We present a method that uses XML doc-uments to describe the parameters for executing a binary.

Excitation of High-Spin States by Inelastic Proton Scattering

This work was supported by National Science Foundation Grant PHY 76-84033 and Indiana Universit

Excitation of High-Spin States by Inelastic Proton Scattering

This work was supported by National Science Foundation Grant PHY 75-00289 and Indiana Universit

Surface superconductivity and order parameter suppression in UPt3_3

We show that a recent measurement of surface superconductivity in UPt$_3$ (Keller {\it et. al.}, Phys. Rev. Lett. {\bf 73}, 2364 (1994)) can be understood if the superconducting pair wavefunction is suppressed anisotropically at a vacuum to superconductor interface. Further measurements of surface superconductivity can distinguish between the various phenomenological models of superconducting UPt$_3$.Comment: 4 pages, latex, 2 Figures available upon request ([email protected]